Name: Cajun Shrimp Skillet with Creamy Sauce Recipe
Prep time: 15 min
Cook time: 25 min
Total time: 40 min
Cuisine: Cajun
Ingredients: 1 lb. uncooked shrimp, peeled and deveined; 1 teaspoon Cajun seasoning; 1 red bell pepper, diced; 1 tablespoon olive oil or avocado oil; 3 tablespoons butter; 3 cloves garlic, minced; 3 tablespoons flour; 1 ½ cups chicken broth; ¾ cups heavy cream (can substitute half and half); 1 tablespoon honey; 2 teaspoons hot sauce; 10 oz. Rotel diced tomatoes with green chilies, juice reserved (about ¼ cup juice); ¾ cup cheddar jack cheese, shredded; 2 teaspoons lime juice; 2 teaspoons Cajun seasoning; 1 teaspoon brown sugar (light); ½ teaspoon mustard powder; ½ teaspoon oregano; 1 pinch cayenne pepper; 1 pinch red pepper flakes; Lime wedges; Fresh cilantro, roughly chopped

There’s something truly comforting about the spicy warmth of Cajun flavors paired with a rich, dreamy sauce, and that’s exactly why this Cajun Shrimp Skillet with Creamy Sauce Recipe deserves a spot on your dinner rotation. It’s a perfect weeknight meal that feels a little fancy but comes together quickly.

A black pan filled with a creamy orange sauce layered with many pink and orange shrimp scattered evenly across the surface. Bright green lime wedges are placed between the shrimp, with small red tomato chunks mixed throughout the dish. The sauce looks smooth and rich, garnished lightly with small green herb bits. The pan rests on a white marbled surface. photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Cajun Shrimp Skillet with Creamy Sauce Recipe
Top Tip
How to Serve Cajun Shrimp Skillet with Creamy Sauce Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Cajun Shrimp Skillet with Creamy Sauce Recipe

Why You'll Love This Recipe

I honestly look forward to making this Cajun Shrimp Skillet with Creamy Sauce Recipe because it satisfies that craving for bold, layered flavors without spending all day in the kitchen. Plus, it’s so versatile and delicious, you’ll find yourself making it again and again.

Bold flavor combination: The Cajun spices bring a gentle kick that blends beautifully with the creamy sauce and melty cheese.
Fast and easy: You can have this ready in under 40 minutes, making it perfect for busy weeknights.
Great for versatility: Whether you serve it over rice, pasta, or with a fresh salad, it pairs well and feels indulgent.
Big on leftovers: The creamy sauce stays luscious when reheated, so you actually look forward to next-day meals.

Ingredients & Why They Work

Every ingredient here plays a role in layering traditional Cajun taste with rich, creamy comfort. I like to buy quality shrimp and fresh produce to make the flavors really sing.

Flat lay of a dozen large raw shrimp with shells removed and tails intact, a small mound of bright red diced bell pepper, a small white ceramic bowl of golden olive oil, a few cloves of whole fresh garlic, a small white ceramic bowl of pale yellow butter cubes, a small white ceramic bowl of fine white flour, a small white ceramic bowl of rich chicken broth, a small white ceramic bowl of thick heavy cream, a small white ceramic bowl of golden honey, a small white ceramic bowl of vivid red hot sauce, a small white ceramic bowl of diced fresh tomatoes with green chili slices, a small white ceramic bowl of shredded creamy cheddar jack cheese, a small white ceramic bowl of fresh lime juice, a small white ceramic bowl of mixed Cajun seasoning powder, a small white ceramic bowl of light brown sugar, a small white ceramic bowl of pale yellow mustard powder, a small white ceramic bowl of dried oregano leaves, a small white ceramic bowl of cayenne pepper powder, a small white ceramic bowl of crushed red pepper flakes, several bright green lime wedges, and a small bunch of roughly chopped fresh cilantro leaves, all arranged symmetrically and balanced on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Shrimp: I prefer large (26-30 count per pound), peeled and deveined—fresh or frozen—and make sure to pat them dry before seasoning to get a good sear.
Cajun seasoning: Adds authentic spice blend without the need to measure a dozen spices yourself.
Red bell pepper: Brings a sweet crunch that balances the heat and creaminess.
Olive oil or avocado oil: Great for high-heat sauté with a mild flavor that won’t overpower the shrimp.
Butter and garlic: The base of the sauce that adds richness and savory depth.
Flour: Thickens the sauce beautifully without clumping when cooked properly.
Chicken broth and heavy cream: Give the sauce its luscious texture and help carry the flavors.
Honey and hot sauce: Balance heat and sweetness for that perfectly rounded sauce.
Rotel tomatoes with green chilies: Adds a subtle zing and a touch of acidity; I always save the juice to deglaze the pan for extra flavor.
Cheddar Jack cheese: Melts smoothly and brings a mild, creamy tang.
Seasonings (mustard powder, oregano, cayenne, red pepper flakes): These deepen the spice profile without overpowering the dish.
Lime juice: Adds a fresh brightness that really lifts the creamy sauce.
Lime wedges and fresh cilantro (for serving): The perfect fresh and zesty garnish to finish everything off.

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Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

One of the best parts about this Cajun Shrimp Skillet with Creamy Sauce Recipe is how easy it is to tweak. I like to add my own spin depending on season or what’s in my pantry.

Variation: I sometimes throw in a handful of black beans or corn when adding the tomatoes for extra texture and a hint of sweetness – it feels hearty and adds nutrition.
Heat Level: If you prefer milder dishes, just reduce the hot sauce and skip the cayenne and red pepper flakes, and your family will thank you!
Dairy-Free: Swap the butter for olive oil and try coconut cream or cashew cream as a substitute for heavy cream – it’s surprisingly good.
Protein Swap: I’ve used chicken breast strips or even firm tofu instead of shrimp—just adjust cooking times to keep everything tender.

Step-by-Step: How I Make Cajun Shrimp Skillet with Creamy Sauce Recipe

A white bowl filled halfway with white rice on the left side, with plump shrimp covered in a light orange creamy sauce placed on the right side, mixed with small pieces of red tomato. The shrimp are sprinkled with green herbs, and a lime wedge and a sprig of cilantro rest on top at the back of the bowl. The bowl sits on a white marbled surface with a light gray cloth partially visible on the right side. photo taken with an iphone --ar 2:3 --v 7

Step 1: Prep the Shrimp and Flavor Base

First off, make sure your shrimp are fully thawed and patted dry—this step is key to getting that beautiful sear rather than steaming them. I like to sprinkle the shrimp evenly with Cajun seasoning for a bold, spicy kick. While the shrimp marinate for a few minutes, drain your Rotel tomatoes but reserve the juice—you’ll thank me later when it helps deglaze the pan and adds a ton of flavor to the sauce. Also, mix your broth, cream, honey, hot sauce, and spices in a bowl and set that aside—this mixture turns into the creamy, dreamy sauce you’re about to fall in love with.

Step 2: Sauté Shrimp and Red Bell Peppers

Heat your olive or avocado oil over medium-high heat (medium high is important to get a nice caramelization). Add shrimp and diced red bell peppers, cooking for about 1 minute plus 20 seconds per side. Set a timer to avoid overcooking—shrimp cook fast and become rubbery if left too long! When they’re just opaque and pink, transfer them to a clean plate, knowing they’ll finish cooking gently when added back to the sauce.

Step 3: Build the Creamy Cajun Sauce

Now drizzle that reserved tomato juice into the pan, turning the heat down to medium. Use a spatula to scrape up all those tasty browned bits stuck to the skillet—this is flavor gold. Let the tomato juice reduce by half to concentrate the flavor. Next, add butter and garlic; cook just about a minute until aromatic. Stir in the flour and cook for two minutes, stirring constantly so you don’t get lumps or the raw flour taste. Slowly whisk in your broth and cream mixture in small splashes while stirring, bringing it to a gentle boil before reducing the heat to low for a simmer.

Fold in the drained tomatoes and let everything simmer uncovered for about 10 minutes. This step is magical—the sauce thickens, the flavors deepen, and it becomes irresistibly creamy. Sprinkle in your shredded cheddar jack cheese gradually, stirring all the while until it melts smoothly. Finally, stir in fresh lime juice for a bright pop of acidity.

Step 4: Combine and Serve

Return the shrimp and peppers to the skillet, folding them gently into the sauce. Remove the pan from heat, add some freshly chopped cilantro on top, and tuck a handful of lime wedges around the edge. This dish pairs beautifully over fluffy chicken broth–cooked rice or buttered noodles. I always suggest freshly squeezed lime at the table to personalize each bite even more.

Top Tip

After cooking this dish a bunch of times, I’ve learned a few tricks that really take it from good to memorable—and I want to share those so you nail it on your first try.

Shrimp Searing: Make sure shrimp are dry before seasoning to get that perfect sear instead of steaming it—use a paper towel and be gentle so they don’t start cooking prematurely.
Timer Alerts: Use a timer when cooking shrimp for precision; overcooked shrimp turns rubbery fast, and 1 min + 20 seconds per side is just right.
Deglazing Magic: Don’t skip reserving the Rotel juice—deglazing the skillet with it pulls up all those caramelized bits that make the sauce pop with flavor.
Cheese Choice: Always shred your cheese fresh from a block. Pre-shredded varieties have anti-caking agents that stop cheese from melting smoothly and give a less creamy texture.

How to Serve Cajun Shrimp Skillet with Creamy Sauce Recipe

Garnishes

I personally love topping this skillet with a generous handful of cilantro because it adds freshness and color, plus some wedges of lime on the side for squeezing right before you dig in. The lime juice brightens the rich sauce perfectly and keeps every bite lively.

Side Dishes

My go-to side for this is fluffy rice cooked in chicken broth to soak up all that creamy sauce. Sometimes I make buttered egg noodles or simple garlic bread to mop up the sauce as well. A crisp green salad with vinaigrette also balances the richness with some acidity and crunch.

Creative Ways to Present

For a fun dinner party, I've served this Cajun Shrimp Skillet with Creamy Sauce Recipe in individual cast iron skillets. It makes for a rustic presentation and keeps the dish warm longer. Another idea is to pile the shrimp and sauce over creamy grits for a Southern twist that’s sure to impress.

Make Ahead and Storage

Storing Leftovers

Once cooled, I store leftovers in an airtight container in the fridge. It keeps well for up to 3 days—just know the shrimp soak up the sauce a bit more as they sit, making every bite taste even better.

Freezing

I’ve frozen this dish successfully by portioning it into freezer-safe containers. It’s best frozen without rice or noodles, so you can prepare fresh starches when you reheat. It freezes well for up to 3 months without losing that creamy texture.

Reheating

When reheating, I let the dish thaw fully in the fridge overnight. Then I gently warm it on the stovetop over medium heat, stirring often. If you heat it too fast or at too high a temperature, the shrimp can get tough, so take it slow and steady to maintain that creamy sauce and tender shrimp.

Frequently Asked Questions:

Can I use frozen shrimp for this recipe?

Absolutely! Just make sure the shrimp are fully thawed and patted dry before cooking; this helps you get that perfect sear and avoids watery sauce.

What can I substitute for Rotel tomatoes if I can't find them?

You can use regular diced tomatoes and add a bit of diced jalapeño or green chili to mimic the mild heat and flavor. Adjust the seasoning accordingly to keep the Cajun vibe.

Can I make this recipe dairy-free?

Yes! Swap butter for olive or avocado oil, and use a coconut milk cream or cashew cream instead of heavy cream. Omit the cheese or use a dairy-free cheese alternative.

How spicy is the Cajun Shrimp Skillet with Creamy Sauce Recipe?

It has a moderate heat level, but you can easily adjust it by reducing the hot sauce and eliminating cayenne pepper and red pepper flakes if you prefer milder flavors. The creamy sauce helps mellow the spice nicely.

Final Thoughts

This Cajun Shrimp Skillet with Creamy Sauce Recipe remains one of my all-time favorites to whip up when I want something that feels both special and comforting. The balance between spice, creaminess, and fresh brightness always hits the spot, and I hope once you try this, it becomes one of your kitchen staples too. Give it a go—you’ll enjoy every delicious bite!